Genetic Modifiers of the Breast Tumor Microenvironment
نویسندگان
چکیده
منابع مشابه
Genetic Contributions of the Tumor Microenvironment in Breast Cancer Metastasis
Metastasis is a multistage process involving many complex genetic events which facilitate the spread and growth of cancer cells at a secondary site. In vivo models of metastasis are invaluable to our understanding of the interactions between cancer cells and a variety of cell types at the metastatic microenvironment. The objective of this study is to first understand how different in vivo model...
متن کاملA Mimic of the Tumor Microenvironment on GPR30 Gene Expression in Breast Cancer
Introduction: The G-protein coupled receptor 30 (GPR30) gene is a member of the G-protein coupled receptor (GPCR) family; involved in breast, endometrial, and ovarian cancers. Many GPCR receptors that are implicated in several types of human cancers are correlated with increased cell proliferation and tumor progression; especially GPR30 gene. Methods: The breast cancer MCF-7 and MDA-MB-231 cel...
متن کاملInterleukin-6 in the Breast Tumor Microenvironment
Greater than 200,000 new cases of breast cancer cases were diagnosed in 2010 in the United States, with approximately 40,000 women succumbing to the disease (www.cancer.gov). Globally, an estimated 1.38 million new cases of breast cancer were diagnosed in 2008, with greater than 450,000 women succumbing to the disease (Jemal et al., 2011). Despite our improved understanding of breast carcinogen...
متن کاملThe tumor microenvironment and inflammatory breast cancer
Inflammatory breast cancer (IBC) is a rare and very aggressive subtype of breast cancer with clinical manifestations similar to acute inflammation. The prognosis of IBC is still poor even though combination therapy with surgery, chemotherapy, and target therapy, mainly due to a lack of fully understanding of the cellular and molecular mechanisms of IBC pathogenesis and progression. In the prese...
متن کاملGenetic instability induced by the tumor microenvironment.
The tumor microenvironment is characterized by regions of fluctuating hypoxia, low pH, and nutrient deprivation. To determine the genetic consequences of growth under these conditions, we used a tumorigenic cell line carrying a recoverable, chromosomally based lambda phage shuttle vector designed to report mutations without the need for genetic selection of mutant cells. The cells were grown in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Cancer
سال: 2018
ISSN: 2405-8033
DOI: 10.1016/j.trecan.2018.04.003